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Leupeptin hemisulfate (Synonyms: 亮肽素)
发布时间:2021-09-02
浏览数:1447

关键词
亮抑酶肽
摘要
Leupeptin hemisulfate 是一种可透过膜的巯基蛋白酶抑制剂,可抑制 Cathepsin B, Cathepsin H 和 Cathepsin L,并损害两性溶酶体的融合。Leupeptin hemisulfate 也具有抗炎作用。
商品信息
商品编号商品名称CAS号纯度规格型号标准价购 买
AD-040-1g 亮抑酶肽103476-89-798%1g8000.00

资料内容
 

生物活性

Leupeptin hemisulfate is a membrane-permeable thiol protease inhibitor that inhibits Cathepsin BCathepsin H and Cathepsin L, and also impairs amphisome-lysosome fusion[1]. Leupeptin hemisulfate also exhibits anti-inflammatory effect[2].

IC50 & Target

Cathepsin[1]

体内研究
(In Vivo)

Leupeptin (0-36 mg/kg; intraperitoneal injection; for 4 hours; C57BL/6NCrl male mice) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2]..

Animal Model:

C57BL/6NCrl male mice (6-8 weeks old, 20-25 g)[2]

Dosage:

0 mg/kg, 9 mg/kg, 18 mg/kg, 36 mg/kg

Administration:

Intraperitoneal injection; for 4 hours

Result:

Promoted the accumulation of LC3b-II in mouse liver.

分子量

475.59

Formula

C??H??N?O? . ?/?H?SO?

CAS 

103476-89-7

Sequence Shortening

Ac-LLR-CHO

中文名称

亮肽素

SMILES

O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4]

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder

-    80°C

2 years

-20°C

1 year

In solvent

-80°C

6 months

-20°C

1 month

溶解性数据

In Vitro: 

H2O : ≥ 19 mg/mL (39.95 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM

2.1027 mL

10.5133 mL

21.0265 mL

5 mM

0.4205 mL

2.1027 mL

4.2053 mL

10 mM

0.2103 mL

1.0513 mL

2.1027 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献

[1]. Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42.

[2]. Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.


 

 

 
                                                                                                             
 

 

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